Package: BIGL
Type: Package
Title: Biochemically Intuitive Generalized Loewe Model
Version: 1.8.0
Date: 2023-06-13
Author: Heather Turner, Annelies Tourny, Olivier Thas, Maxim Nazarov,
        Rytis Bagdziunas, Stijn Hawinkel, Javier Franco Pérez
Maintainer: Maxim Nazarov <maxim.nazarov@openanalytics.eu>
Description: Response surface methods for drug synergy analysis.
        Available methods include generalized and classical Loewe
        formulations as well as Highest Single Agent methodology.
        Response surfaces can be plotted in an interactive 3-D plot and
        formal statistical tests for presence of synergistic effects
        are available. Implemented methods and tests are described in
        the article "BIGL: Biochemically Intuitive Generalized Loewe
        null model for prediction of the expected combined effect
        compatible with partial agonism and antagonism" by Koen Van der
        Borght, Annelies Tourny, Rytis Bagdziunas, Olivier Thas, Maxim
        Nazarov, Heather Turner, Bie Verbist & Hugo Ceulemans (2017)
        <doi:10.1038/s41598-017-18068-5>.
License: GPL-3
Depends: R (>= 3.5)
Imports: ggplot2, MASS, methods, minpack.lm, numDeriv, parallel,
        progress, plotly, robustbase, scales, nleqslv, data.table
Suggests: knitr, rmarkdown, testthat, shiny, DT
VignetteBuilder: knitr, rmarkdown
LazyData: true
URL: https://github.com/openanalytics/BIGL
BugReports: https://github.com/openanalytics/BIGL/issues
Encoding: UTF-8
RoxygenNote: 7.2.3
Config/pak/sysreqs: cmake make libicu-dev libuv1-dev libssl-dev
Repository: https://openanalytics.r-universe.dev
Date/Publication: 2023-06-13 13:52:34 UTC
RemoteUrl: https://github.com/openanalytics/bigl
RemoteRef: HEAD
RemoteSha: e6e06d93482d23548b29c35ec4bffbc926bfa1f2
NeedsCompilation: no
Packaged: 2026-06-15 09:23:16 UTC; root