Changes in version 1.8.0 (2023-06-13)                  

  - new function synergy_plot_bycomp() to create plots for 2D
    cross-section of response surfaces from different null models
  - fix small bugs in plot.effect-size and plotResponseSurface functions

                 Changes in version 1.7.0 (2023-03-08)                  

  - switch from rgl to plotly for the 3D plots
  - move NEWS to NEWS.md

                 Changes in version 1.6.7 (2023-01-26)                  

  - replace rgl.* functions due to upcoming deprecation in the rgl
    package

                 Changes in version 1.6.6 (2022-05-05)                  

  - skip further tests on CRAN that may fail randomly

                 Changes in version 1.6.5 (2021-10-27)                  

  - skip some tests on CRAN that may fail randomly

                 Changes in version 1.6.4 (2021-09-02)                  

  - Fix vignettes to avoid CRAN warnings on systems without pandoc or
    webshot2

  - Make sure NAs in bootConfint are handled

                 Changes in version 1.6.3 (2021-06-29)                  

  - Fix code for compatibility with new ggplot2 version

                 Changes in version 1.6.2 (2021-03-10)                  

  - Fix issue with testing when variance at off-axis points equals zero

                 Changes in version 1.6.0 (2020-12-16)                  

  - Residual resampling according to mean-variance trend

  - Use bootstrapped confidence intervals for point-by-point and overall
    effect sizes

  - Internal redesign for speed-up, using "d1d2" identifiers

                 Changes in version 1.5.3 (2020-09-10)                  

  - fix issue with generalizedLoewe and hsa functions when data is a
    tibble

                 Changes in version 1.5.2 (2020-07-24)                  

  - fix issue with smooth monotherapy plot when dotted line was not
    shown due to numeric inaccuracies

                 Changes in version 1.5.1 (2020-07-07)                  

  - show smooth prediction curve on the marginal fit plot

  - show warning for agonist/antagonist combination when using
    generalized Loewe model

                 Changes in version 1.4.3 (2020-02-20)                  

  - fixes for special case of 2 flat monotherapy profiles

                 Changes in version 1.4.2 (2020-01-20)                  

  - even better support for flat monotherapies, consistent calls/colors
    for all representations (contour plot, summary table and 3d plot)

  - added clarification to description of Bliss method in the
    "Methodology" vignette

  - fixed typos

                 Changes in version 1.4.1 (2019-06-21)                  

  - improve tests

                        Changes in version 1.4.0                        

  - added Alternative Loewe independence null model

                 Changes in version 1.3.0 (2019-02-28)                  

  - added Bliss independence null model

                 Changes in version 1.2.3 (2018-11-21)                  

  - better support for flat monotherapies

                 Changes in version 1.2.2 (2018-09-10)                  

  - make sure if no replicates are there model/unequal method is not
    allowed

                        Changes in version 1.2.1                        

  - fix regression bug to allow custom axis labels for the contour plot

                 Changes in version 1.2.0 (2018-06-13)                  

  - support heterogeneous variance with new argument 'method' for
    'fitSurface'

                        Changes in version 1.1.3                        

  - show EC50 in log10 terms for monotherapy summary

  - allow custom compound names for plotting

                        Changes in version 1.1.2                        

  - fix monotherapy formula in the vignette

                 Changes in version 1.1.1 (2018-01-03)                  

  - added reference to the original article

  - fix DESCRIPTION file according to new R CMD check policy

                 Changes in version 1.1.0 (2017-09-25)                  

  - isobologram() plot is now available for ResponseSurface objects It
    is also now included in the shiny app.

  - summary.ResponseSurface does not fail if marginal fits have
    constraints

  - Change of package maintainer

                        Changes in version 1.0.3                        

  - Contour plot for maxR now has correct p-value labels

  - Summary for marginal fits does not fail if Hessian computation
    failed

                        Changes in version 1.0.2                        

  - extra arguments in fitMarginals are now passed to the optimizer
    functions

                 Changes in version 1.0.1 (2017-06-30)                  

  - predict method added for the MarginalFit objects

                         Changes in version 1.0                         

  - Initial public release